Another drug that is a candidate anticorrosiveness vaccine, developed by American biologists at the University of North Carolina, writes Liga.net.
In the United States experienced the “humanized” mice vector vaccine against SARS-CoV-2, based on the LaSota strain of Newcastle disease virus (NDV), which modernized the coronavirus S-protein. The result is posted on the Preprint server bioRxiv.
The experiments were carried out in the laboratory 3rd — maximum — level biosecurity.
Nine groups of mice were immunizable four different variants of the vaccine in a dosage of 10 and 50 mcg for a three-week scheme Prime-boost (the first vaccination+fixing). Injection was done intramuscularly, as a live NDV is almost not replicated in the muscle and does not cause symptoms in mammals.
Newcastle disease or the Asian bird plague — a viral disease of birds. The animals develop pneumonia, encephalitis, and multiple petechial hemorrhages in the organs. Pathogen — RNA-paramyxovirus — poses a great threat to poultry with regard to its high sensitivity to the virus and the mortality of 15-30%.
The virus is harmless for humans: may cause high mild conjunctivitis and flu-like symptoms.
The authors claim that their drug in all doses “caused a high level of neutralizing antibodies”. Attempt nasal (through the nose) to infect the immunized animal coronavirus were in vain: the virus and its antigens in the lungs after this experiment was not detected.
This vaccine is offered to perform a traditional and relatively cheap for many similar products of way — in chicken eggs with embryos.
NDV is a safe platform for vaccines. This virus is also used for research with the development of antitumor vaccines: it can selectively hit onkokletki.