Opening team of scientists from Cardiff University may allow physicians “to set” the human immune system against cancer cells. This may open the way to a universal cure for cancer. About it writes BBC.
The method has not yet been clinically tested, but the researchers say that it’s got huge potential. A summary of the work was published in the journal Nature Immunology.
The essence of the research was to search for “unusual” ways in which the immune system fights off cancerous tumors.
Scientists have discovered a special type of T-lymphocyte cells, which in humans is responsible for the immune response.
However, the scientists found the cell, unlike others, can counteract various types of threats.
“There’s a chance that it could cure all patients. Previously, nobody thought that was possible,” said researcher Henry Sewell.
How it works
On the surface of T lymphocytes (or T cells), there are chemical receptors by which they determine the antigens that are dangerous for the body.
The team of scientists managed to find a way to get a view of T lymphocytes attack a wide range of cancer cells.
The method would be tested on cells lung cancer, blood cancer, colon, breast, bone, prostate, ovaries and cervix.
Lymphocytes destroy cancer cells without touching healthy.
How is the T-lymphocyte differentiates cancer cells from healthy, is not yet clear. Its receptor interacts with a molecule called MR1, which is on the surface of every cell in the human body.
It is believed that cancer cells “use” MR1 masking from the immune system. However, discovered in Cardiff T-lymphocytes, the researchers believe, can get from MR1 the signal that the cell metabolism is disturbed, and that is a cell of the tumor.
“We are the first to describe T-cell detection in cancer cells MR1. It couldn’t be done,” says researcher Harry Dalton.
This study is not the first in its field. Setting up experiments the immune system against cancer are long enough.
The most famous of them — CAR-T. This means against leukemia preprogrammed the immune system to counteract this type of cancer. In the case of CAR-T T-lymphocytes genetically preprogrammed to find and destroy cancer cells.
Then the modified cells returned to the patient’s body, where their number increases each time when they encounter cancer cells.
Katrine Johns has been a reporter on the news desk since 2013. Before that she wrote about young adolescence and family dynamics for Styles and was the legal affairs correspondent for the Metro desk. Before joining The Gal Post, Katrine Johns worked as a staff writer at the Village Voice and a freelancer for Newsday, The Wall Street Journal, GQ and Mirabella. To get in touch, contact me through my email@example.com 1-800-268-7128